Rat bites and scratches can result in disease and rat-bite fever. Rat urine is responsible for the spread of leptospirosis, which can result in liver and kidney damage. It can also be contracted through handling or inhalation of scat. Complications include renal and liver failure, as well as cardiovascular problems.
Lymphocytic choriomeningitis (LCMV), a viral infectious disease, is transmitted through the saliva and urine of rats. Some individuals experience long-term effects of lymphocytic choriomeningitis, while others experience only temporary discomfort.
One of the most historically dangerous rat-borne diseases is the bubonic plague, also called “Black Plague,” and its variants. Transfer occurs when fleas from the rats bite human beings.
Rats also are a potential source of allergens. Their droppings, dander and shed hair can cause people to sneeze and experience other allergic reactions.
Leptospirosis. This is a bacterial disease that can be transmitted by coming into contact with infected water by swimming, wading or kayaking or by contaminated drinking water. Individuals may be at increased risk of Leptospirosis infections if they work outdoors or with animals.
Source: https://buff.ly/2GYNAlx (You can also check other diseases caused by rats on this link)
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